Dr. Clarke's areas of interest include depression treatment/prevention, child and adolescent mental health and treatments, and treatment of substance abuse comorbid with mental disorders. Dr. Clarke has been the principal investigator and co-investigator of several grants funded by the National Institute of Mental Health, conducting controlled outcomes trials of depression treatment and prevention in at-risk populations.

Some of his most recent controlled trials examine the costs and clinical outcomes of preventing and treating depression in adolescent offspring of depressed parents enrolled in an HMO; the medication and psychotherapy treatment of depression in adolescents who have failed to respond to an initial course of SSRI anti-depressant medication; treatment of depression in adults also receiving outpatient treatment for alcohol addiction; simultaneous psychotherapy and medication for depressed adolescents treated in primary care; and Internet self-care programs for depressed adults and adolescents.

Dr. Clarke has been conducting mental health research for 20 years. He received his Ph.D. in Clinical Psychology from the University of Oregon in 1985.

Current Studies:

	Brief, Primary Care CBT for Unmedicated Depressed Youth — STAND
	Development of a CBT Model for Adolescent Bulimia Spectrum Disorders—Claire Project
	Prevention of Depression—POD
	Sleep-Wake Disturbances in Adolescents with Chronic Pain—AT-REST
	Treatment of Resistant Depression in Adolescents 2 — TORDIA 2
	Treatment of SSRI-Resistant Depression in Adolescents — TORDIA

Recently Completed Studies:

	Generalized Anxiety Disorder: Burden of Illness Study
	HMO Treatment of Depression Co-morbid with Substance Abuse—SODAS
	Internet-Based Interventions for Youth Disorders—IIP
	Naturalistic Pharmacotherapy for Youth Depression — LEAP
	Psychosocial Treatment of Depression in Delinquents
	Study for Testing Effective Approaches for Depression in Youth— STEADY

E-mail: greg.clarke@kpchr.org