Study Details

The DASH-Sodium Trial: Genetic Determinants of Response—DASH 2 Genetics

William M. Vollmer, Principal Investigator
Emily L. Harris, Co-Investigator

 Essential hypertension results from the interaction of several genetic and environmental factors. Identification of genetic factors that modulate blood pressure regulation and/or blood pressure response to intervention can increase our understanding of hypertension pathophysiology and can lead to improved strategies for prevention and control. The purpose of this study is to identify genes that may modulate blood pressure response to nutritional interventions that lower blood pressure. This genetic association study uses stored blood samples from randomized participants in the DASH-Sodium study to determine the extent to which candidate hypertension genes modulate the blood pressure response to the DASH diet and to reduced sodium intake (i.e., to study the genotype by environment interactions). The Center for Health Research (CHR) is serving as the coordinating center for this project, as it did for the DASH-Sodium trial. In this capacity CHR provides data management expertise; designs and conducts statistical analyses; arranges for transmission and storage of biological samples; and provides logistical support for conference calls and meetings.
Funding source: National Heart, Lung, and Blood Institute, under a subcontract to Duke University Medical Center

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