David H. Smith, RPh, PhD
Senior Investigator

Photo of David Smith

Dr. Smith's research focuses on the economic evaluation of medical interventions and pharmacoepidemiology. He is site principal investigator for the HMO CERTS (Centers for Research & Education on Therapeutics), an AHRQ-funded collaboration of HMOs focusing on pharmacy issues. Dr. Smith is involved in studies analyzing prescribing behavior, medication adherence, drug use and outcomes, and FDA-funded studies on drug safety.

Dr. Smith is conducting other pharmacy related research involving patient safety, including methods to reduce errors through alerting systems in automated physician prescribing. He is currently leading several industry-funded studies on the natural history of chronic kidney disease. He is also leading an Robert Wood Johnson-funded investigation into financial incentives in the treatment of depression in the primary care setting.

Dr. Smith received his pharmacy degree from the University of Washington in 1990. After completing his residency in General/Clinical Pharmacy he worked as a clinical pharmacist in home care. He received an MHA in Health Services Administration in 1995, and was awarded a PhD in Pharmacy Outcomes Research from the University of Washington in 1998. He is an Honorary Visiting Fellow at the University of York, Centre for Health Economics, and is adjunct assistant professor at the University of Washington's School of Pharmacy.

E-mail: David.H.Smith@kpchr.org

Current Studies:
  • A Retrospective Analysis of Hypertension Management in the Patients over age 75 with Chronic Kidney Disease: Is Systolic Blood Pressure of Less than 130 Associated with Benefit or Risk?
  • An Assessment of the Natural History of Chronic Kidney Disease
  • Cardiovascular Outcomes in Adults (CERT ADHD Phase II)
  • Diabetics and Drug-Associated Hyperkalemia: Effect of Laboratory Monitoring—Hyper K
  • Evidence-Based Laboratory Medicine: Quality/Performance Evaluation in CKD—CKD LAB
  • Evidence-based Practice Center—U.S. Preventive Services Task Force
  • HMO Research Network Cardiovascular Research Network—CVRN
  • Lotronex

    Recently Completed Studies:
  • CERT Epidemiological Studies of the Adverse Events of Marketed Drugs
  • Does Equity Matter in Managed Care
  • Excess Rate of All-Cause Mortality Among Patients with Chronic Kidney Disease and Elevated Serum Phosphate
  • Excess Rates of Healthcare Utilization Among Patients with Elevated Parathyroid Values
  • Factors Associated with Gaps in Osteoporosis Treatment—Factors
  • Financial Incentives in Depression — FIND
  • Incidence of Drug-Induced Liver Injury—Chan Liver
  • Kaiser Permanente Northwest's Patients with Heart Failure: Predicting Mortality, Healthcare Costs and Cardiovascular Hospitalization
  • Naturalistic Pharmacotherapy for Youth Depression — LEAP
  • Patients with Chronic Kidney Disease and End-Stage Renal Disease: Predicting Clinical Outcomes, Healthcare Utilization, and Direct Medical Costs in Relation to Anemia Management and Calcium and Phosphorous Management
  • Patients with Chronic Kidney Disease: Developing a Risk Equation to Predict Mortality and Progression to End-Stage Renal Disease
  • Population-based HMO Study of Gout Pharmacoepidemiology-GOUT
  • Prevalence of and Strategies for Appropriate Prescription Medication Dosing for Children – Kids Meds
  • The Community-Based Rates of Psychiatric Events, Suicide-Related Events, Convulsions and Cardiovasular Events According to Patients' Body Mass Index—BIRO
  • The Epidemiology and Natural History of Food Allergies
  • The Refracture Intervention Trial Phase 2—REFIT 2
  • The Use of Angiotension Converting Enzyme Inhibitors (ACEIs) and Chronic Kidney Disease
  • Weight in Secondary Prevention — WISP


    Researchers and Physician Investigators
    The Center for Health Research brings together scientists from a wide variety of fields to study health and medical care.



    Affiliated Investigators
    TCHR clinical investigators and outside collaborators appointed as affiliate investigators
    Emeritus Investigators
    Distinguished retired investigators
    Research Associates
    Scientists supporting investigator research and leading their own investigations.
    Our Leaders
    Leaders of TCHR's scientific direction.
    Kaiser Permanente