Katrina Goddard, PhD

Senior Investigator
Katrina Goddard

Katrina Goddard, PhD, is a genetic epidemiologist who focuses on public health genomics and the translation of genetic testing into practice. She joined the Kaiser Permanente Center for Health Research in 2007.

Dr. Goddard is the principal investigator of a study funded by the National Human Genome Research Institute (NHGRI) that is exploring how to use whole-genome sequencing in everyday clinical practice. The study will test would-be parents for genetic mutations that could cause rare but serious diseases in their children. Couples who get usual care will be compared with couples who get tested with whole-genome sequencing.

Dr. Goddard founded the NW Biobank, a repository of blood and tissue samples linked to health plan members’ comprehensive electronic medical records. The biobank enables researchers to connect people’s genetic information with their health care, such as vital signs, diagnoses, and treatments. This regional biobank was recently assimilated into a national initiative called the Kaiser Permanente Research Bank.

Dr. Goddard directs the Knowledge Synthesis Team and is co-chair of the Actionability Work Group for NHGRI’s ClinGen Consortium. The team provides a detailed summary for each gene or phenotype topic that is used by the work group to produce a semi-quantitative metric score. Other recent research includes implementing screening for Lynch syndrome in a managed care setting and a large comparative effectiveness research project on genomic and personalized medicine for colon cancer (CERGEN).

Prior to her appointment as a Senior Investigator, Dr. Goddard was on the faculty at Case Western Reserve University in the Division of Genetic & Molecular Epidemiology. She was involved in several large-scale gene discovery projects there and was associate director of the Human Genetic Analysis Resource, which produces the SAGE software package. She received her PhD in biostatistics from the University of Washington in 1999 and a BS in molecular biology from the University of Wisconsin-Madison.

E-mail: Katrina.AB.Goddard@kpchr.org

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Recent Publications

Elizabeth M. Webber, Tia L. Kauffman, Elizabeth O’Connor, Katrina A.B. Goddard. Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy. BMC Cancer. 2015 Mar 21;15:156. doi: 10.1186/s12885-015-1093-4.   Full text
Henrikson NB, Webber E, Goddard K, Scrol A, Piper M, Williams MS, Zallen DT, Calonge N, Ganiats TG, Janssens ACJW, Zauber A, Lansdorp-Vogelaar I, van Ballegooijen M, Whitlock E. Family history and the natural history of colorectal cancer: Systematic review. Genet Med. 2015 Jan 15. doi: 10.1038/gim.2014.188. [Epub ahead of print]   PubMed abstract
Schneider JL, Goddard KAB, Davis J, Wilfond B, Kauffman TL, Reiss JA, Gilmore M, Himes P, Lynch FL, Leo MC, McMullen C. "Is it worth knowing?" Focus group participants' perceived utility of genomic preconception carrier screening. J Genet Couns. 2015 Jun 21. [Epub ahead of print]   PubMed abstract
Schneider JL, Davis J, Kauffman TL, Reiss JA, McGinley C, Arnold K, Zepp J, Gilmore M, Muessig KR, Syngal S, Acheson L, Wiesner GL, Peterson SK, Goddard KAB. Stakeholder perspectives on implementing a universal lynch syndrome screening program: A qualitative study of early barriers and facilitators. Genet Med. 2015 Apr 16. doi: 10.1038/gim.2015.43. [Epub ahead of print]   PubMed abstract
Schully SD, Carrick DM, Mechanic LE, Srivastava S, Anderson GL, Baron JA, Berg CD, Cullen J, Diamandis EP, Doria-Rose VP, Goddard KAB, Hankinson SE, Kushi LH, Larson EB, McShane LM, Schilsky RL, Shak S, Skates SJ, Urban N, Kramer BS, Khoury MJ, Ransohoff DF. Leveraging biospecimen resources for discovery or validation of markers for early cancer detection. J Natl Cancer Inst. 2015 Feb 16;107(4). pii: djv012. doi: 10.1093/jnci/djv012. Print 2015 Apr.   Full text
Wilfond B, Goddard KAB. It's complicated: Criteria for policy decisions for the clinical integration of genome scale sequencing for reproductive decision-making. Molecular Genetics and Genomic Medicine. 2015 Jul;3(4):239-42. doi: 10.1002/mgg3.130.   Full text
1. Schully SD, Lam TK, Dotson WD, Chang CQ, Aronson N, Birkeland ML, Brewster SJ, Boccia S, Buchanan AH, Calonge N, Calzone K, Djulbegovic B, Goddard KA, Klein RD, Klein TE, Lau J, Long R, Lyman GH, Morgan RL, Palmer CG, Relling MV, Rubinstein WS, Swen JJ, Terry SF, Williams MS, Khoury MJ. Evidence synthesis and guideline development in genomic medicine: current status and future prospects. Genet Med 2014 Jun 19. [Epub 2014 Jun 19] PMCID: PMC4272332 [Available on 2015/12/19]   Full text
Feigelson HS, Goddard KAB, Hollombe C, Tingle SR, Gillanders EM, Mechanic LE, Nelson SA. Approaches to integrating germline and tumor genomic data in cancer research. Carcinogenesis. 2014 Oct;35(10):2157-63. PMCD: PMC4178473   Full text
Feigelson HS, Zeng C, Pawloski PA, Onitilo AA, Richards CS, Johnson MA, Kauffman TL, Webster J, Niyirenda C, Alexander GL, Hwang C, Cross D, McCarty CA, Davis RL, Schwarzkopf D, Williams AE, Honda S, Daida Y, Kushi LH, Delate T, Goddard KAB on behalf of the CERGEN Study Team. Does KRAS testing in metastatic colorectal cancer impact overall survival? A comparative effectiveness study in a population-based sample. PLoS One. 2014 May 1;9(5):e94977. PMCID: PMC4006772   Full text
Musser ED, Hawkey E, Kachan-Liu SS, Lees, P, Roullet J, Goddard K, Steiner RD, Nigg JT. Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders. J Child Psychol Psychiatry. 2014 Jul;55(7):819-27. PMCID: PMC4211282 [Available on 2015/7/1]   Full text


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