Gregory A. Nichols, PhD

Senior Investigator
Gregory Nichols

Dr. Gregory Nichols' research experience melds scientific training and policy vision with a hands-on understanding of the complexities of obtaining and analyzing health-utilization data.

Dr. Nichols constructed Kaiser Permanente Northwest's Diabetes Registry in 1989 and has used it to conduct health services, economic, and epidemiologic research studies on patients before and after diabetes diagnosis. A recent focus of his work has been anti-hyperglycemic treatment failure in type 2 diabetes, and the development of decision rules to assist clinicians in responding to this type of treatment failure.

Other areas of interest include cardiovascular disease and depression, as well as the precursors to both diabetes and cardiovascular disease, commonly known as metabolic syndrome.

Dr. Nichols is leading the creation of a 12-site diabetes registry that involves HMO research partners from around the United States. Other projects include a study of diabetes incidence for all possible combinations of metabolic syndrome components and costs of medical care associated with components of the metabolic syndrome. Dr. Nichols also led a study of changes in HDL cholesterol and risk of subsequent cardiovascular-disease hospitalization among patients with diabetes. He is a co-investigator on a multi-site study of outcomes related to further intensifying diabetes therapy in patients already on at least two medications, and on another multi-site study on initiating metformin early versus later following diabetes diagnosis.

Before becoming a CHR Investigator, Dr. Nichols served as a senior research associate at CHR, a rate analyst for Kaiser Permanente, and a financial analyst for the Northrop Corporation. He holds a PhD in public administration and policy from Portland State University and an MBA from Pepperdine University.


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Recent Publications

Green CA, Yarborough BJ, Leo MC, Yarborough MT, Stumbo SP, Janoff SL, Perrin NA, Nichols GA, Stevens, VJ. The STRIDE weight loss and lifestyle intervention for individuals taking antipsychotic medications: A randomized trial. Am J Psychiatry, 2015;172(1):71-81. - doi: 10.1176/appi.ajp.2014.14020173. PMCID: PMC4282602 [Available on 2016/1/1]   Full text
Narayanan K, Reinier K, Teodorescu C, Uy-Evanado A, Aleong R, Chugh H, Nichols GA, Gunson K, London B, Jui J, Chugh S. Left Ventricular Diameter and Risk Stratification for Sudden Cardiac Death. J Amer Heart Assoc 2014;3(5):e001193  
Nichols GA, Rosales AG, Perrin NA, Fortmann SP. The association between different A1C-based measures of glycemia and risk of cardiovascular disease hospitalization. Diabetes Care 2014 Jan;37(1):167-72. [Epub 2013 Aug 29] PMCID: PMC3867992 [Available on 2015/1/1]   Full text
Raebel MA, Ellis JL, Schroeder EB, Xu S, O'Connor PJ, Segal JB, Butler MG, Schmittdiel JA, Kirchner HL, Goodrich GK, Lawrence JM, Nichols GA, Newton KM, Pathak RD, Steiner JF. Intensification of antihyperglycemic therapy among patients with incident diabetes: A SUrveillance PREvention and ManagEment of Diabetes Mellitus (SUPREME-DM) study. Pharmacoepidemiology and Drug Safety 2014 Jul;23(7):699-710.  
Schmittdiel JA, Raebel MA, Dyer W, Xu S, Goodrich GK, Schroeder EB, Segal JB, O'Connor PJ, Nichols GA, Lawrence JM, Kirchner HL, Karter AJ, Lafata JE, Butler MG, Steiner JF. Prescription medication burden in patients with newly diagnosed diabetes: A SUrveillance, PREvention, and ManagEment of Diabetes Mellitus (SUPREME-DM study). Journal of the American Pharmacists Association 2014; 54:e251-259.[Epub ahead of print]  
Schmittdiel JA, Steiner JF, Adams AS, Dyer W, Beals J, Henderson WG, Desai J, Morales LS, Nichols GA, Lawrence JM, Waitzfelder B, Butler MG, Pathak R, Hamman R, Manson SM. Diabetes Care and Outcomes for American Indians and Alaska Natives in Commercial Integrated Delivery Systems: A SUrveillance, PREvention, and ManagEment of Diabetes Mellitus (SUPREME-DM) Study. BMJ Open Diabetes Research & Care 2014;2:e000043.  
Vijayadeva V, Nichols G. Impact of implementing glycated hemoglobin testing for identification of dysglycemia in youth. The Permanente Journal 2014 Fall;18(4):21-27.  
Vupputuri S, Kimes, TM, Calloway MO, Christian JB, Bruhn D, Martin AA, Nichols GA. The economic burden of progressive chronic kidney disease among patients with type 2 diabetes. Journal of Diabetes and Its Complications 2014 Jan-Feb;28(1):10-16.  
Winterstein AG, Kubilis P, Bird S, Cooper-DeHoff RM, Nichols GA, Delaney JA. Misclassification in assessment of diabetogenic risk using electronic health records. Pharmacoepidemiology Drug Safety 2014 Jun 12 [Epub ahead of print]  
Cooper-DeHoff RM, Bird ST, Nichols GA, Delaney JA, Winterstein AG. Antihypertensive Drug Class Interactions and Risk for Incident Diabetes: A Nested Case-Control Study. J Am Heart Assoc 2013;2:e000125 doi: 10.1161/JAHA.113.000125  

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