Gregory A. Nichols, PhD

Senior Investigator
Gregory Nichols

Dr. Gregory Nichols' research experience melds scientific training and policy vision with a hands-on understanding of the complexities of obtaining and analyzing health-utilization data.

Dr. Nichols constructed Kaiser Permanente Northwest's Diabetes Registry in 1989 and has used it to conduct health services, economic, and epidemiologic research studies on patients before and after diabetes diagnosis. A recent focus of his work has been anti-hyperglycemic treatment failure in type 2 diabetes, and the development of decision rules to assist clinicians in responding to this type of treatment failure.

Other areas of interest include cardiovascular disease and depression, as well as the precursors to both diabetes and cardiovascular disease, commonly known as metabolic syndrome.

Dr. Nichols is leading the creation of a 12-site diabetes registry that involves HMO research partners from around the United States. Other projects include a study of diabetes incidence for all possible combinations of metabolic syndrome components and costs of medical care associated with components of the metabolic syndrome. Dr. Nichols also led a study of changes in HDL cholesterol and risk of subsequent cardiovascular-disease hospitalization among patients with diabetes. He is a co-investigator on a multi-site study of outcomes related to further intensifying diabetes therapy in patients already on at least two medications, and on another multi-site study on initiating metformin early versus later following diabetes diagnosis.

Before becoming a CHR Investigator, Dr. Nichols served as a senior research associate at CHR, a rate analyst for Kaiser Permanente, and a financial analyst for the Northrop Corporation. He holds a PhD in public administration and policy from Portland State University and an MBA from Pepperdine University.

E-mail: Greg.Nichols@kpchr.org

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Recent Publications

Nichols GA, Rosales AG, Perrin NA, Fortmann SP. The association between different A1C-based measures of glycemia and risk of cardiovascular disease hospitalization. Diabetes Care 2014 Jan;37(1):167-72. [Epub 2013 Aug 29] PMCID: PMC3867992 [Available on 2015/1/1]   Full text
Raebel MA, Ellis JL, Schroeder EB, Xu S, O'Connor PJ, Segal JB, Butler MG, Schmittdiel JA, Kirchner HL, Goodrich GK, Lawrence JM, Nichols GA, Newton KM, Pathak RD, Steiner JF. Intensification of antihyperglycemic therapy among patients with incident diabetes: A SUrveillance PREvention and ManagEment of Diabetes Mellitus (SUPREME-DM) study. Pharmacoepidemiology and Drug Safety 2014  
Vupputuri S, Kimes, TM, Calloway MO, Christian JB, Bruhn D, Martin AA, Nichols GA. The economic burden of progressive chronic kidney disease among patients with type 2 diabetes. Journal of Diabetes and Its Complications 2014;28:10-16.  
Cooper-DeHoff RM, Bird ST, Nichols GA, Delaney JA, Winterstein AG. Antihypertensive Drug Class Interactions and Risk for Incident Diabetes: A Nested Case-Control Study. J Am Heart Assoc 2013;2:e000125 doi: 10.1161/JAHA.113.000125  
Feldstein A, Schneider J, Unitan R, Perrin N, Smith DH, Nichols GA, Lee NL. Health care worker perspectives inform optimization of patient panel-support tools: A qualitative study. Population Health Management 2013 Apr; 16(2):107-19. [Epub 2012 Dec 5]   PubMed abstract
Neugebauer R, Fireman B, Roy JA, Raebel MA, Nichols GA, O'Connor PJ. Super Learning to Hedge Against Incorrect Inference from Arbitrary Parametric Assumptions in Marginal Structural Modeling. J Clin Epi 2013 Aug;66(8 Suppl):S99-S109. doi: 10.1016/j.jclinepi.2013.01.016.   Full text
Nichols GA, Joshua-Gotlib S, Parasuraman S. Glycemic Control and Risk of Cardiovascular Disease Hospitalization and All-Cause Mortality. J Am Coll Cardiol 2013;62:121-127.  
Nichols GA, Joshua-Gotlib S, Parasuraman S. Independent contribution of A1C, systolic blood pressure, and LDL cholesterol control to risk of cardiovascular disease hospitalizations in Type 2 Diabetes An observational cohort study. Journal of General Internal Medicine 2013 Jan 24. [Epub 2013 Jan 24]   PubMed abstract
Raebel MA, Xu S, Goodrich GK, Schroeder EB, Schmittdiel JA, Segal JB, O’Connor PJ, Nichols GA, Lawrence JM, Kirchner HL, Elston Lafata J, Butler M, Newton KM, Steiner JF. Initial Antihyperglycemic Drug Therapy Among 241 327 Adults With Newly Identified Diabetes From 2005 Through 2010: A Surveillance, Prevention, and Management of Diabetes Mellitus (SUPREME-DM) Study. Ann Pharmacother. 2013;47(10):1280–1291.   PubMed abstract
Desai JR, Wu P, Nichols GA, Lieu TA, O'Connor PJ. Diabetes and asthma case identification and representativeness when using electronic health data to construct registries for comparative effectiveness and epidemiologic research. Medical Care 2012; 50:S30-S35.   PubMed abstract


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