Gregory A. Nichols, PhD

Senior Investigator
Gregory Nichols

Dr. Gregory Nichols' research experience melds scientific training and policy vision with a hands-on understanding of the complexities of obtaining and analyzing health-utilization data.

Dr. Nichols constructed Kaiser Permanente Northwest's Diabetes Registry in 1989 and has used it to conduct health services, economic, and epidemiologic research studies on patients before and after diabetes diagnosis. A recent focus of his work has been anti-hyperglycemic treatment failure in type 2 diabetes, and the development of decision rules to assist clinicians in responding to this type of treatment failure.

Other areas of interest include cardiovascular disease and depression, as well as the precursors to both diabetes and cardiovascular disease, commonly known as metabolic syndrome.

Dr. Nichols is leading the creation of a 12-site diabetes registry that involves HMO research partners from around the United States. Other projects include a study of diabetes incidence for all possible combinations of metabolic syndrome components and costs of medical care associated with components of the metabolic syndrome. Dr. Nichols also led a study of changes in HDL cholesterol and risk of subsequent cardiovascular-disease hospitalization among patients with diabetes. He is a co-investigator on a multi-site study of outcomes related to further intensifying diabetes therapy in patients already on at least two medications, and on another multi-site study on initiating metformin early versus later following diabetes diagnosis.

Before becoming a CHR Investigator, Dr. Nichols served as a senior research associate at CHR, a rate analyst for Kaiser Permanente, and a financial analyst for the Northrop Corporation. He holds a PhD in public administration and policy from Portland State University and an MBA from Pepperdine University.


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Recent Publications

Green CA, Yarborough BJH, Leo MC, Stumbo SP, Perrin NA, Nichols GA, Stevens VJ. Weight maintenance following the STRIDE lifestyle intervention for individuals taking antipsychotic medications. Obesity (Silver Spring). 2015 Oct;23(10):1995-2001. PMCID: PMC4586363 [Available on 2016-04-01]   Full text
LeBlanc ES, Rosales AG, Kachroo S, Mukherjee J, Funk KL, Schneider JL, Nichols GA. Provider beliefs about diabetes treatment have little impact on glycemic control of their patients with diabetes. BMJ Open Diabetes Res Care 2015 Feb 24;3(1):e000062. PMCID: PMC4342519   Full text
Nichols GA, Reynolds K, Kimes TM, Rosales AG, Chan WW. Comparison of risk of re-hospitalization, all-cause mortality and medical care resource utilization in patients with heart failure and preserved versus reduced ejection fraction. American Journal of Cardiology. 2015 Jul 15. pii: S0002-9149(15)01627-6. doi: 10.1016/j.amjcard.2015.07.018. [Epub ahead of print]   PubMed abstract
Nichols GA, Rosales AG, Kimes TM, Tunceli K, Kurtyka K, Mavros P, Steiner JF. Impact on glycated haemoglobin of a biological response-based measure of medication adherence. Diabetes Obes Metab. 2015 Apr 16. doi: 10.1111/dom.12476. [Epub ahead of print]   PubMed abstract
Reynolds K, Butler MG, Kimes TM, Rosales AG, Chan W, Nichols GA. Relation of Acute Heart Failure Hospital Length of Stay to Subsequent Readmission and All-Cause Mortality. Am J Cardiol 2015;116(3):400-405  
Schmittdiel JA, Nichols GA, Dyer W, Steiner JF, Karter AJ, Raebel MA. Health Care System-level Factors Associated With Performance on Medicare STAR Adherence Metrics in a Large, Integrated Delivery System. Med Care 2015 Apr;53(4):332-7. PMCID: PMC4359632 [Available on 2016-04-01]  
Schroeder EB, Desai J, Schmittdiel JA, Paolino AR, Schneider JL, Goodrich GK, Lawrence JM, Newton KM, Nichols GA, O'Connor PJ, Fitz-Randolph M, Steiner JF. An Innovative Approach to Informing Research: Gathering Perspectives on Diabetes Care Challenges From an Online Patient Community. Interact J Med Res 2015 Jun 30;4(2):e13.  
Schroeder EB, Powers JD, O'Connor PJ, Nichols GA, Xu S, Desai JR, Karter AJ, Morales LS, Newton KM, Pathak RD, Vazquez-Benitez G, Raebel MA, Butler MG, Lafata JE, Reynolds K, Thomas A, Waitzfelder BE, Steiner JF; SUPREME-DM Study Group. Prevalence of chronic kidney disease among individuals with diabetes in the SUPREME-DM Project, 2005-2011. J Diabetes Complications. 2015 Jul;29(5):637-43. doi: 10.1016/j.jdiacomp.2015.04.007. Epub 2015 Apr 16.   PubMed abstract
Vazquez-Benitez G, Desai JR, Xu S, Goodrich GK, Schroeder EB, Nichols GA, Segal J, Butler MG, Karter AJ, Steiner JF, Newton KM, Morales LS, Pathak RD, Thomas A, Reynolds K, Kirchner HL, Waitzfelder B, Elston Lafata J, Adibhatla R, Xu Z, O'Connor PJ. Preventable Major Cardiovascular Events Associated With Uncontrolled Glucose, Blood Pressure, and Lipids and Active Smoking in Adults With Diabetes With and Without Cardiovascular Disease: A Contemporary Analysis. Diabetes Care. 2015 May;38(5):905-12. doi: 10.2337/dc14-1877. Epub 2015 Feb 20.   PubMed abstract
Green CA, Yarborough BJ, Leo MC, Yarborough MT, Stumbo SP, Janoff SL, Perrin NA, Nichols GA, Stevens, VJ. The STRIDE weight loss and lifestyle intervention for individuals taking antipsychotic medications: A randomized trial. Am J Psychiatry, 2015;172(1):71-81. [Epub 2014 Oct 31] PMCID: PMC4282602 [Available on 2016/1/1]   Full text

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